Until May 2016 Mpho Letlape was Deputy Vice Chancellor for Strategic Services at the University of Johannesburg. Before that she held the positions of Managing Director – Sasol Inzalo Foundation and Vice President – Sasol Foundation; Managing Director for the HR Division at Eskom; and Human Resources Director at IBM South. Other boards she has sat on include Air Traffic and Navigation Services, T-Systems South Africa (TSSA), South African Post Office, Eskom (executive), Institute for People Management (chairman), South African Business Coalition on HIV and Aids (chairman), she chaired the TSSA Foundation, was a trustee on the UNISA Foundation. She is currently Executive Chair of Lethushane Pty Ltd, a property development company operating in Ekurhuleni, Gauteng that she founded in 2012. It showcases social entrepreneurship, driven by the need for affordable decent housing, chronic unemployment, and the devastation both these bring.